Besides an extensive range of genetic and epigenetic alterations, components of the tumor microenvironment tend to exert a significant impact on tumor progression. The so-called tumor ...

This combination therapy showed significant tumor growth delay and improved survival rates in preclinical models, suggesting that integrin-targeted imaging can play a role in optimizing ...

Integrins are very attractive therapeutic targets in oncology. The anti-tumor mechanisms of integrin-targeting drugs have been validated both in vitroand in vivo. Integrin-targeting drugs are ...

Backgrounds: Collagen type I alpha 1 chain (COL1A1) is a key protein encoding fibrillar collagen, playing a crucial role in the tumor microenvironment (TME) due to its complex functions and close ...

Single-cell RNA sequencing revealed that loss of JAM-A did not influence the transcriptional reprogramming of myeloid cells in the tumor microenvironment. Overall ... A3-1), CD11c (HL3), NK1.1 (PK136) ...

An immuno-oncology targeting panel accurately characterized tumor-resident immune cells and located pathologically and clinically relevant tumor microenvironment features. Cancer development and ...

1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts. 2Department of Biological Engineering, Massachusetts Institute of Technology, ...

Imaging its expression would allow the efficacy of anti-angiogenic drugs in patients to be predicted. However, most studies used animal models with integrin αvβ3 expression on the tumor cell surface.