Mayo Clinic researchers have identified a targeted therapy that could bring relief to people living with lichen planus, a ...

Mayo Clinic researchers have identified a targeted therapy that could bring relief to people living with lichen planus, a ...

Regulatory T cells typically inhibit other immune cells, including those that produce interferon gamma. Knocking out calcium signaling in regulatory T cells unleashed the cells that produce ...

The Katherine King lab members are involved in the study of the role of interferon-gamma in hematopoietic stem cell regulation. Dr. King discusses the impact of receiving an AAMDSIF research grant on ...

Interferon gamma (IFN-γ) is a cytokine that induces ... These interleukins’ stimulatory effects also result from intracellular signaling of transcription factors such as AP-1, JAK/STAT, and ...

The investigators concluded that SOCS1 needs to exceed a threshold level to inhibit both IFN-gamma and GM-CSF signaling. Furthermore, “the ability of SOCS1 to cross-regulate GM-CSF signaling is ...

Dazukibart, a type I interferon inhibitor, reduced dermatomyositis disease severity while maintaining a well-tolerated safety ...

[Courtesy of Brandao et al., Science Translational Medicine/AAAS.] Compared with microglia from untreated mice, those from animals exposed to the xenon dialed down expression of pro-inflammatory ...