(1) T cells are isolated from the patient's peripheral blood through leukapheresis. (2) These cells are activated using anti-CD3/CD28 antibodies to stimulate their proliferation. (3) Genetic ...

Here, in bone marrow transplantation and organoid culture models, T-cell-derived Interferon-γ is shown to promote STAT1-dependent intestinal stem cell c-MYC expression and epithelial regeneration.

Jeroen A. J. M. van de Water, Tugba Bagci-Onder [...] Khalid Shah The authors note that Fig. 1J appeared incorrectly. The corrected figure and its legend appear below. The online version has been ...

It is administered through intrathecal and intravenous infusion route. The therapeutic candidate constitutes autologous T cells armed with bi-specific antibody produced by hetero conjugation of ...

TCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610075, Sichuan, China Oncology Teaching and Research ...

Background: Enterobacteria and cytokines both play roles in the pathophysiology of NSAID-induced enteropathy. Toll-like receptor (TLR) 4 recognises lipopolysaccharide (LPS), resulting in activation of ...

Summary: New research reveals that certain cells inactivate one parent’s copy of a gene, leading to a bias in gene activity that may explain why some individuals with disease-causing mutations remain ...

This study presents a valuable finding on a potential signaling pathway responsible for the direct effects of nicotine on intestinal ... in Paneth cells. The inhibition of Notch signaling by ...

Whereas, all models are restricted to mice, lacking analysis of human samples or human intestinal organoids to prove the human relevance of these findings. Overall, the presented results support their ...

This target product profile (TPP) highlights the minimal and optimal characteristics for ex-vivo and in-vivo cell and gene therapy-based products aimed at achieving an HIV ... 1 Due to the persistence ...

Getting a clearer picture Previous research has found differences in gene expression between humans and chimpanzees, and that human cells tend to have higher gene expression, but the picture was ...