However, many people with obesity have leptin resistance, meaning their brains don’t process the hormone effectively, so they frequently feel hungry. Over time, that can lead to obesity.

A significant aspect of obesity is the development of leptin resistance, primarily due to the inefficient transport of leptin across the blood-brain barrier and other mechanisms such as protein ...

These changes result in dynamic alteration of adipokine production that reflect the severity of obesity, chronic inflammation with the infiltration of macrophages, leptin resistance, and altered ...

Obesity, recognized as a complex and growing health issue, is associated with an increased risk of various cancers. A comprehensive review provides insights into the mechanisms linking obesity to ...

Koreans who are obese or overweight are less likely to kill themselves than those who are of average weight or under, a study ...

Although rare in humans, leptin mutations in mice result in leptin deficiency and lead to early onset obesity, hyperphagia, and hypothalamic hypogonadism. Unlike leptin deficient mice, humans ...