Here we explore peptide inhibitors of Cdc20, a substrate-recognition subunit and activator of the E3 ubiquitin ligase the anaphase promoting complex/cyclosome (APC/C) that is essential in mitosis and ...

Substrate and inhibitor binding are distinguished by major TM rearrangements and their ligand binding chemistry, with TM4 playing a central role in all conformational transitions. Furthermore, our ...

Department of Chemistry, Illinois Institute of Technology, Chicago, Illinois 60616, United States ...

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today announced a five-year strategic alliance to accelerate the clinical evaluation and development of Myriad’s molecular residual disease (MRD) assay. This strategic alliance brings together ...

Abstract: The development of intelligent methods capable of predicting protein-ligand binding sites has become a popular research field. Recently, deep learning based methods have been proposed as a ...

To study differences in lipid profiles between raft domains, the MALDI-MS assay was performed on RMMAs. To evaluate the preservation of native protein activities (enzymatic activity and ligand binding ...

In 1999, Allred and colleagues reported that the ER status by immunohistochemistry (IHC) is superior to the ligand-binding assay (LBA) for predicting outcomes with ET in BC (3). In the Allred scoring ...

Subsequent medicinal chemistry and molecular biology studies identified major ligand binding and receptor domains (Hjorth et al ... In this study we deployed multiple assays to study the pharmacology ...