One significant discovery in the field is the identification of a human RNA ligase, C12orf29, which catalyzes ATP-dependent RNA ligation. This enzyme was found to be essential for maintaining RNA ...

Regardless of the route exploited, each enzyme involved in the installation ... including the Staudinger ligation of azides with functionalized phosphines and the [3+2] cycloaddition of azides ...

The team evaluated more than 4,000 clones before identifying an enzyme S N Ar1.3 that contains six mutations and is 160-fold more active than the parent enzyme.

Background: Liver injury is one of the serious complications of sepsis. Previous studies suggested that dexmedetomidine (DEX) could alleviate cecal ligation and puncture (CLP)-induced liver injury.

pH is a measure of how acidic or alkaline a solution is. The diagram below shows what happens to an enzyme when denaturation occurs. Each enzyme has an optimum pH but it also has a working range ...

This manuscript describes an important finding of the transcriptional control of a chimeric gene transfer agents (GTA) cluster in Bartonella by a processive anti-termination factor (BrrG). The ...

Elevated liver enzymes can occur for many reasons. Most often, elevated liver enzymes are temporary and resolve on their own without treatment. Occasionally, elevated liver enzymes require additional ...

How cells respond to mitochondrial DNA (mtDNA) damage is not fully understood. This study uncovers a mechanism of mtDNA ...

Coronavirus disease 2019 (COVID-19) is an acute respiratory disease caused by a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which has no specific and effective treatment. The ...

Men have two birth control options: condoms and vasectomies. Why has it taken so long to develop more contraceptives?

Temperature affects enzyme-catalysed reactions by influencing the rate at which they occur. For a reaction to occur between an enzyme and substrate the two molecules need to collide. At lower ...

The engineered enzymes had similar gene-editing efficiency and reduced immune responses compared to standard nucleases in mice. Appearing today in Nature Communications, the findings could help ...