4.1 STAT3 regulates macrophage polarization through the JAK/STAT signaling pathway JAK/STAT is a main signaling pathway for the activation of more than 70 cytokines, and it plays an important role in ...

In the other direction, M1 polarized macrophages inhibit the proliferation and viability of MSCs and impair their ability to immunosuppress the environment, preventing cartilage repair. Therefore, ...

(2) do environmental signals affect macrophage accumulation? and (3) how do bacterium derived-factors stimulate a unique macrophage subset to promote inflammation and tumour cell proliferation? By ...

The management of Leishmania donova ni (LD), responsible for fatal visceral leishmaniasis (VL), faces increasing challenges due to rising drug-unresponsiveness, leading to increasing treatment ...

Monoallelic loss of PTEN and ARID1A is identified in normal colonic epithelium. The resulting haploinsufficient phenotypes ...

Design Flow cytometry, immunohistochemistry, confocal imaging and gene expression analyses determined the phenotype, functional/transcriptomic profile and tissue topography of MerTK+ ...

Nearly 60,000 people are diagnosed with oral cancer in the U.S. every year, according to the American Cancer Society, and the ...

Corticosteroids inhibit antigen presentation, cytokine production, and proliferation of lymphocytes ... The monocyte effect. Monocytes/macrophages (promonocytes in the bone marrow, circulating ...

Although only transiently expressed, the pre-BCR marks an important checkpoint in B-cell development and regulates diverse processes, such as proliferation, allelic exclusion of the second heavy ...

UC San Diego researchers have identified the molecular and cellular mechanisms that transform healthy stem cells into oral cancer at the earliest stages of the disease ...