This study unveiled the role of Lrrk2 gene in regulating macrophage polarization and immune response. This finding provides ...

In obese individuals, macrophages enter a pro-inflammatory state known as M1 polarization, which contributes to chronic inflammation. This polarization promotes tissue damage, inflammation and ...

smu.edu.cn, baixc15{at}smu.edu.cn Objectives To investigate the roles and regulatory mechanisms of synovial macrophages and their polarisation in the development of osteoarthritis (OA). Methods ...

This study focused on exosomes derived from stem cells of human exfoliated deciduous teeth (SHED-MSC-EXOs) and their role in managing the balance of immunoregulatory macromolecules that play a role in ...

Monocytes and macrophages are myeloid cells that have important innate immune functions. Macrophages reside in tissues and respond to infection by producing inflammatory mediators and engulfing ...

The underlying regulatory mechanisms of metabolic switching are assessed by both in vitro and in vivo studies. Conclusions Selectively modulating the ‘context’ of glycolytic macrophages in HCC tumours ...

中性粒细胞和巨噬细胞是抵御病原体微生物感染的重要免疫细胞。在病原体入侵时，中性粒细胞率先被招募到感染部位，通过吞噬、产生活性氧（ROS）等方式发挥抗菌作用，同时其释放的 NETs 也备受关注。NETs 由双链 DNA、组蛋白和非组蛋白蛋白质组成，在调节免疫反应中发挥重要作用。巨噬细胞则可分化为 M1 和 M2 两种类型，M1 型巨噬细胞分泌促炎细胞因子，增强免疫反应；M2 ...

Background The immune suppression mechanisms in pancreatic ductal adenocarcinoma (PDAC) remain unknown, but preclinical studies have implicated macrophage-mediated immune tolerance. Hence, pathways ...

Spinal cord injury (SCI) is characterized by the temporary or permanent loss of motion or sensation function caused by damage to the spinal cord. Among the mechanisms behind SCI, neuroinflammation is ...