Membrane proteins are proteins found in cell membranes, either at the surface or on intracellular organelles. Integral membrane proteins such as receptors and ion channels span the membrane.

Small extracellular vesicles are membrane-bound vesicles secreted into extracellular spaces by virtually all types of cells. These carry a large number of membrane proteins on their surface that are ...

The method presents a strong foundation for broader applications in identifying physiologically and pharmacologically relevant membrane protein-ligand interactions. Integral membrane proteins (IMPs) ...

Enhertu first secured approval in 2019 for patients with high levels of HER2, a protein that promotes cancer cell growth. In ...

It does that by talking to the membrane fusion protein." More information: Chanwoo Lee et al, Exocyst stimulates multiple steps of exocytic SNARE complex assembly and vesicle fusion, Nature ...

While the data support key aspects of protein recruitment and membrane remodeling, missing controls and statistical analysis information, unaddressed discrepancies, and limitations in recapitulating ...

A temporally resolved CRISPR-Cas9 screen reveals DAC-induced DNA damage drives trans-cell cycle cytotoxicity that depends on ...

Recombinant proteins, which represent the largest proportion of biopharmaceutical products ... This terminal structure [Galβ(1,3)(Fucα(1,4))GlcNAc], known as Lewis A (Le a) epitope, appears ...

Researchers compared the effects of RNA molecules delivered by EVs with and without the membrane protein to mice with ailing hearts. Only molecules carried by EVs with ion channels were able to ...

The LNP-mRNA modality is a novel approach that uses lipid nanoparticles to deliver messenger RNA into cells. The mRNA acts as ...