Two protocols for switching between carvedilol, a third-generation nonselective agent with vasodilation through α 1 blockade, and a β 1-selective agent (e.g., metoprolol, atenolol) are described ...

Metoprolol is used for phenotyping of cytochrome P450 (CYP) 2D6, a CYP isoform considered not to be inducible by inducers of the CYP2C, CYP2B, and CYP3A families such as rifampicin. While assessing ...

After hours: February 4 at 5:28:51 PM EST ...

Maack et al. [70] recently reported on switching between β blockers (metoprolol and carvedilol) in 68 patients treated with either agent for 1 year who had improved in terms of LVEF and NYHA class.

Pregnancy and associated physiologic changes affect the pharmacokinetics of many medications, including selective serotonin reuptake inhibitors—the first-line pharmacologic interventions for ...

With historical data showing migraine to be underdiagnosed and undertreated, new guidance from the American College of ...

Specifically, COPERNICUS (led in the UK by Professor Coats at Imperial) showed general efficacy of beta-blockers in heart failure; COMET (designed and led by Professor Poole-Wilson at Imperial) showed ...

With the advancements of molecular genetics and the identification of mutations in the genes encoding the cardiac ryanodine receptor and cardiac calsequestrin 2 in patients with CPVT, the central role ...

The term dilated cardiomyopathy (DCM) refers to a spectrum of heterogeneous myocardial disorders that are characterized by ventricular dilation and depressed myocardial performance in the absence of ...