Others have produced little spheres of human neural tissue by combining neurons, astrocytes, and microglia, all derived from induced pluripotent stem cells. Neurons in this system were more active ...

“By understanding the blood vessel-neuron interactions and understanding the underlying mechanisms, we hope to develop new drugs or strategies to manage the neuropathic pain,” Zhang said.

The work will be of interest to neuroscientists working on glia-neuron interaction and synaptic remodeling. In the nervous system, reliable communication depends on the ability of neurons to ...

The study, published in the journal Neuron, highlights microglia, the brain's primary immune cells, as central players in both the protective and harmful responses associated with the disease.

This study presents a valuable finding on the function of the gene Cst7 in sex-divergent pathological changes in microglia in a mouse model of amyloid-driven Alzheimer's disease. The evidence ...

NG2 cells, or polydendrocytes, are a population of CNS cells that are distinct from neurons, mature oligodendrocytes, astrocytes and microglia. They can be identified by the expression of the NG2 ...

The involvement of immunity in psychiatric disorders, such as anxiety, is typified by the morphologic adaptation of microglia, immune cells of the brain, to anxiogenic stimuli. We previously reported ...

There is a need for reliable and easy to manipulate models that allow studying the mechanisms behind neuron and glia communication ... compared with microglia alone. Astrocytes reduced expression of ...