In 2000, it was suggested to me that “Autophagy will be the wave of the future; it will become the new apoptosis.” Few people would have agreed at the time, but this statement turned out to be ...

A report published in PLoS Biology provides evidence that PTEN-induced putative kinase 1 (PINK1) is involved in selective autophagy of dysfunctional mitochondria. Recessive mutations in the PINK1 ...

Here, the researchers review the involvement of mitochondrial and autophagy dysfunction in neurodegenerative disorders specifically focusing on Alzheimer's, Parkinson's and Huntington's disease ...

We are driven to understand the signals regulating tissue-specific autophagy signalling in mammalian health and disease. Understanding the physiological regulation and significance of selective ...

The transferred mitochondria trigger the cell to destroy its low-performing mitochondria through autophagy—a kind of cellular ...

Autophagy loss increases PC vulnerability, independent of its role in protein and mitochondria quality control. Credit: Nature Metabolism (2025). DOI: 10.1038/s42255-024-01196-4 ...

Hitherto his scientific breakthroughs regard the characterisation of pathways governing homeostasis of mitochondria and their quality control regulation via targeted autophagy (mitophagy). His ...