Here, the researchers review the involvement of mitochondrial and autophagy dysfunction in neurodegenerative disorders specifically focusing on Alzheimer's, Parkinson's and Huntington's disease ...

Autophagy can mediate the specific removal of stressed or damaged cytoplasmic organelles, including mitochondria and the ER. Undoubtedly, there are multiple connections between the apoptotic and ...

"Our research demonstrates that autophagy isn't just about clearing damaged mitochondria or protein aggregates," explained first author Dr. Janine Tutas. "In Purkinje cells, ATG5 actively ...

Selective processes related to autophagy, such as mitophagy, were studied to evaluate the impact of damaged mitochondrial clearance on aging neurons. The roles of key proteins such as the ...

A report published in PLoS Biology provides evidence that PTEN-induced putative kinase 1 (PINK1) is involved in selective autophagy of dysfunctional mitochondria. Recessive mutations in the PINK1 ...

This process, known as autophagy, is like a self-cleaning mechanism for cells, ... Recycling takes place in our cells at all times: in a process called autophagy, cell components that are no ...

We are driven to understand the signals regulating tissue-specific autophagy signalling in mammalian health and disease. Understanding the physiological regulation and significance of selective ...

Hitherto his scientific breakthroughs regard the characterisation of pathways governing homeostasis of mitochondria and their quality control regulation via targeted autophagy (mitophagy). His ...

Autophagy loss increases PC vulnerability, independent of its role in protein and mitochondria quality control. Credit: Nature Metabolism (2025). DOI: 10.1038/s42255-024-01196-4 ...