Normal metabolic activity produces reactive oxygen species (ROS) that, if not eliminated, can damage cellular components. As a result, ROS from overactive mitochondria are frequently cited as a source ...

as assessed by TUNEL assay. Meanwhile, edelfosine induced a time- and concentration-dependent generation of ROS in yeasts. Rotenone, an inhibitor of the mitochondrial electron transport chain ...

The Agilent Seahorse XF Mito Tox Assay kit allows for the identification of drug-induced mitochondrial toxicity through direct functional measurements of mitochondrial oxygen consumption rates (OCR).

Reversing mitochondrial damage could help cure diabetes Regardless of the cell type, the researchers found that damage to the mitochondria did not cause cell death. This observation brought up the ...

Regardless of the cell type, the researchers found that damage to the mitochondria did not cause cell death. This observation brought up the possibility that if they could reverse the damage ...

Some mitochondrial genes have disappeared completely; others have been transferred to our cells’ nuclei for safekeeping, away from the chemically harsh environment of the mitochondrion. This is akin ...