Proteins containing a hydrophobic sorting signal are released into the inner mitochondrial membrane (IMM), while hydrophilic proteins are imported into the matrix with the help of the presequence ...

Proteomic studies revealed that mitochondria contain ∼1,000 (in yeast) to 1,500 (in humans) different proteins and led to the recent identification of new mitochondrial import pathways and ...

Mitochondrial autophagy (or mitophagy ... proteins. LC3-I is conjugated to membrane-resident phosphatidylethanolamine (PE) and converted to LC3-II. LC3 has the potential to recognize and engulf ...

Mitochondria are critical for cellular homeostasis, regulating bioenergetics, redox balance, Ca2+ signaling, and cell death. Mitochondrial Ca2+ ...

mitochondrial membrane potential loss, and permeability transition pore activation, which can culminate in cell death. A review by a team of researchers at the Chinese Academy of Science ...

mitochondrial membrane potential loss, and permeability transition pore activation, which can culminate in cell death. A review by a team of researchers at the Chinese Academy of Science ...

Mitochondria are essential for generating energy that fuels cells and helps them function. Mitochondrial defects, however, are associated with the development of diseases such as type 2 diabetes.

A thermal stability-based proteomic analysis identifies cytoplasmic PEBP1 as a mediator of mitochondrial dysfunction-induced stress response, highlighting its potential role in cellular adaptation ...

The FDA has extended the review period for the New Drug Application for elamipretide for the treatment of Barth syndrome.

Disparate pathogenic mechanisms complicate precision-medicine efforts to treat diffuse large B-cell lymphoma (DLBCL), the most common lymphoma diagnosis. Though potentially curable with frontline ...