proposing that mitochondria are the source of the free radicals. As Harman’s free-radical theory of aging took hold, it fueled research into cancer, Alzheimer’s and many other diseases.

Vijg describes this genome and discusses the significance of DNA damage to mitochondria, which may be an important signaling factor in the aging process. A leading theory of aging, which he ...

(Mitochondrial DNA, in contrast ... Key Concepts in the Genetic Theory of Aging The key concepts in genetics and aging include several important concepts and ideas ranging from telomere shortening ...

The PAMRP theory combines these two perspectives ... species and the link between metabolism and aging-related factors like entropy and mitochondrial function. Caloric restriction, which is ...

Ziegler and his team also discovered that if mitochondria does not have enough NAD stored up, it can have a fatal consequence for the cell. “Our study connects two hallmarks of aging ...

Researchers observed the largest lifespan extension when they targeted the catalase to mitochondria, which are thought to be the major cellular source of reactive oxygen species (ROS) such as hydrogen ...