Deficiency of S100A4 also ameliorated fibrosis in the tight-skin-1 (Tsk-1) mouse model. Conclusions We characterised S100A4 as a downstream mediator of the stimulatory effects of TGF-β on fibroblasts ...

thus maintaining the homeostasis of embryonic development and adult systems under normal physiological conditions. For example, stimulation with TGF-βs induces cytostasis in almost all mammalian cells ...

Finally, combining anti-TGF-β therapy with other cancer therapy is an attractive venue to be explored for the treatment of therapy-resistant cancer. FIGURE 1. TGF-β signaling pathway TGF-β transduces ...

MSCs also impair B-cell functions, such as antibody production ... which indicates that MSCs might be a new strategy for the treatment of immune-mediated diseases. Mesenchymal stem cells (MSCs ...

1 Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany 2 First Faculty of Medicine, Department of Rheumatology, Institute of ...

The resulting PCL–Zn (PZ) nanofibers effectively guided the growth of NIH3T3 fibroblasts for 7 days, forming a fibroblast cell sheet ... The scaffolds were fixed in 4% paraformaldehyde and treated ...

But a new mouse study shows one possible use case for xenon — as a treatment for Alzheimer’s disease. The paper, published Wednesday in Science Translational Medicine, shows the potential of ...

Institute of Systems and Physical Biology, Shenzhen Bay Laboratory, Gaoke Innovation Center, Guangming District, Shenzhen, Guangdong 518132, P. R. China ...

It appears that President Donald Trump has masterfully channeled a quiet rage that has built up among voters who get great service at McDonald’s but are then treated like meat by motor vehicle ...