PDH promotes the entry of pyruvate into mitochondria via MPC and its conversion to acetyl coenzyme A, which initiates TCA by inhibiting the activity of LDH ... phosphofructokinase-1 (PFK); silencing ...

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MKO cells also have higher levels of mitochondrial NADH, suggesting increased substrate availability, which supports a higher NADH production rate and serves as an indicator of TCA cycle efficiency.

Figure 2 Generalised overview of respiration including glycolysis in the cytosol; pentose phosphate pathway in the cytosol and plastids; tricarboxylic acid (TCA) cycle and oxidative phosphorylation in ...

aCenter for Renal Translational Medicine/Institute for Metabolomic Medicine, University of California San Diego, San Diego, CA, United States bDepartment of Clinical and Molecular Medicine, Faculty of ...