NLRP3 and NLRC4/NAIP5) NLRs that regulate other cellular responses such as type-I IFN production or MHC molecule expression (e.g., NLRC5 and NLRP12) Many NLR functions and ligands remain unknown.

Jupiter, Florida, Jan. 13, 2025 (GLOBE NEWSWIRE) -- Jupiter Neurosciences, Inc. (NASDAQ: JUNS) (“Jupiter” or the “Company”), a clinical-stage pharmaceutical ...

The NLRP3 inflammasome is a key inflammation driver linked to central nervous system (CNS) disorders, metabolic diseases, and aging-related conditions. JOTROL, Jupiter’s flagship product ...

【导读】NLRP3介导的炎症反应在先天免疫功能中起着至关重要的作用，但NLRP3炎性小体在调节酒精性肝病（ALD）肠稳态和肠道上皮屏障方面的作用尚不 ...

Background: The nod-like receptor family pyrin domain-containing 3 (NLRP3) has been implicated in various skin diseases. However, its role in mediating 2, 4-dinitrofluorobenzene (DNFB)-induced chronic ...

we investigated whether apigenin attenuates NLRP3 inflammasome activation in human monocytes and monocyte derived macrophages through CD38 inhibition. Ultrapure LPS from Escherichia coli (O111:B4), ...