To achieve functional recovery and repair of the nigrostriatal tract ... further evidence of changes in the underlying neuronal pathways. These findings show that endogenous progenitor cells ...

Previous animal studies have suggested the involvement of those pathways in the neurodegeneration occurring in the nigrostriatal pathways. However, since most animal α-synucleinopathy models do ...

in particular those associated with the nigrostriatal dopaminergic pathway. There is now robust experimental evidence for a neuroprotective effect of nicotine upon dopaminergic neurons.