Ferroptosis was determined by MDA levels, SOD levels, mitochondrial iron accumulation and ROS production. Ferroptosis-related proteins Slc7a11, Nrf2 and Gpx4 levels were measured by western blot, ...

We further treated the cells with CHIR99021, an activator of the Wnt signaling pathway. The results showed that CHIR99021 activated the GSK3β/β-catenin signaling pathway and reversed the PFOA-induced ...

As a crucial regulator of redox balance, nuclear factor erythroid 2-related factor 2 (Nrf2) governs the transcription of downstream antioxidant enzymes (Huang et al., 2022; Shen et al., 2019). Under ...