Findings indicate that altering glucose metabolism in T cells boosts their therapeutic potential against melanoma, paving the way for improved immunotherapies.

The purpose of this study was to investigate whether circulating pyruvate kinase M2 (PK‐M2) levels are elevated in the peripheral blood and to assess their association with diagnosis and prognosis in ...

The researchers have now come a step closer to mapping this island by discovering the shortest-lived superheavy nucleus known so far, which marks the position of the island's shoreline in nuclei ...

A new milestone in nuclear physics has been achieved with the direct observation of three different deformations in the atomic nucleus of lead-190 (190 Pb). These deformations, associated with ...

We further examined the consequences of sampling islet heterogeneity in 2D compared to 3D. Finally, we investigated the role of the glycolytic enzymes glucokinase and pyruvate kinase in controlling ...

During glycolysis, glucose is metabolized to pyruvate. In normoxic conditions, pyruvate enters the mitochondria and ... a PTM that facilitates its interaction with the primary transcript of the MAP ...

State Key Laboratory of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, PR China State Key Laboratory of Macromolecular Drugs and Large-scale Preparation, School ...

This enzyme links the two stages of cellular respiration: glycolysis and the citric acid cycle. In doing so, pyruvate dehydrogenase helps regulate the metabolic plasticity of cells. The researchers ...

This month's cover highlights the article Breast cancer secretes anti-ferroptotic MUFAs and depends on selenoprotein synthesis for metastasis by Tobias Ackermann, Saverio Tardito and colleagues. The ...

Here, we found that cells before DPCA showed staining in the cytoplasm, but after DPCA, staining was seen in the nucleus where Oct ¾ acts as a transcription factor and is key to self-renewal of ...