Current research has shown that the administration of opioids ... very different mechanisms. An allosteric model suggests that the binding of a ligand to a population of delta receptors results ...

The global burden of anxiety- and depression-related disorders is on the rise. While multiple drugs have been developed to ...

Depression continues to grapple a large proportion of the population. Given the side effects associated with the long-term use of conventional antidepressants, there is a need for novel rapid acting ...

Reversing opioid overdoses in rats using a drug that does not enter the brain prevents the sudden and severe withdrawal symptoms associated with therapeutics that target the central nervous system.

The precise mechanism of action is not known but the effects are thought to be mediated through opioid-specific receptors located in the CNS. Use lowest effective dose for shortest duration.

A study showed that changes in the functioning of opioid neurotransmitters in the brain may underlie anorexia.

Codeine sulfate is an opioid agonist relatively selective ... although the exact mechanism of analgesic action remains unknown. Serious and life-threatening risks from use of Codeine Sulfate ...

Purpose. Published reports on placebo-controlled clinical trials and other studies investigating the use of pure opioid antagonists for the prevention and treatment of opioid-induced pruritus (OIP ...

2006;40(11):2178-2186. The mechanism of action of fentanyl is best described by its agonist interaction with the opioid µ-receptor. These sites of interaction are primarily distributed throughout ...

Tris Pharma has pointed to a phase 3 win for its pain relief drug as demonstrating the candidate’s potential to help resolve the opioid crisis. | Tris Pharma has pointed to a phase 3 win for its pain ...