The important pro-fibrotic factors among them include transforming growth factor (TGF)- , connective tissue growth factor (CTGF), platelet-derived growth factor (PDGF), Interleukins ... on the role of ...

CTGF is involved in several signaling pathways that contribute to inflammation, fibrosis, and cancer development. Recent studies have highlighted the promising outcomes of drugs targeting CTGF ...

Several signaling molecules and transcription factors have been identified ... In addition, PPAR-d agonists prevent hepatic fibrosis in experimental rodent models. Many fibrogenic agonists such as ...

[78] Several potent non-selective tyrosine kinase inhibitors that interrupt both VEGF and PDGF signaling have been approved for cancer therapy: imatinib, sorafenib, pazopanib, sunitinib ...

Fibroblasts from eight normal controls, seven patients with interstitial fibrosis associated with a collagen vascular disease (IP-CVD), and 13 patients with sarcoidosis were also examined. Migratory ...

In the subarachnoid space, CTGF contributes to pia mater fibrosis by promoting the synthesis and deposition of extracellular matrix components. In the non-canonical Smad signaling pathway, the ...

It is now well established that PSC are responsible for producing the stromal reaction (fibrosis) of two major diseases of the pancreas—chronic pancreatitis and pancreatic cancer. Despite ...

The aim of this study is to investigate the role of somatostatinergic and cytokine signalling in hepatic stellate cells (HSC), the effector cells of hepatic fibrosis. Methods The production of ...

[20] Fibrosis and its extension in hepatic tissue is most common evidence of cirrhosis. Several indexes are available to predict cirrhosis but no method or score is available on exclusive basis to ...

同时，伤口愈合市场在研发、工艺、临床以及初始投入方面有非常高的门槛，作为目前港股市场唯一一家聚焦PDGF药物研发的稀缺标的，华芢生物将 ...