[78] Several potent non-selective tyrosine kinase inhibitors that interrupt both VEGF and PDGF signaling have been approved for cancer therapy: imatinib, sorafenib, pazopanib, sunitinib ...

In the subarachnoid space, CTGF contributes to pia mater fibrosis by promoting the synthesis and deposition of extracellular matrix components. In the non-canonical Smad signaling pathway, the ...

The aim of this study is to investigate the role of somatostatinergic and cytokine signalling in hepatic stellate cells (HSC), the effector cells of hepatic fibrosis. Methods The production of ...

TSP-1 mRNA and protein were detected in quiescent and activated cultured hepatic stellate cells (HSC) and TSP-1 expression was highly inducible by platelet derived growth factor BB (PDGF-BB) and, to a ...

Background: Severe Community-Acquired Pneumonia (SCAP) is a serious global health issue with high incidence and mortality rates. In recent years, the role of biomarkers such as Connective Tissue ...

The S&P 500 finishes the year 23.5% higher, bolstered by strong corporate profits and artificial intelligence investment and enthusiasm. LPL Research expects stocks to move higher in 2025, but ...

The research indicates that macrophages previously described as "pro-fibrotic" are insufficient to cause fibrosis on their own, opening the door to research that can help advance the understanding ...

According to the daily charts, this exchange-traded fund with a high dividend yield of 3.67% has been under pressure as it has fallen below its short-term moving averages in the oversold territory.

The study provides valuable insights into the mechanisms underlying neurovascular coupling; the authors present solid evidence demonstrating that layer II/III pyramidal neurons can induce ...