[78] Several potent non-selective tyrosine kinase inhibitors that interrupt both VEGF and PDGF signaling have been approved for cancer therapy: imatinib, sorafenib, pazopanib, sunitinib ...

Furthermore, existing marketed anti-VEGF agents are being studied in combination with novel PDGF inhibitors for dual therapy. Thus, it is important to consider the history of VEGF antagonists for ...

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Regenerative medicine has significantly impacted orthopaedic surgery by introducing biological therapies aimed at repairing, ...

Diabetes is a leading cause of global mortality and disability, and its economic burden is substantial. This Review focuses on type 2 diabetes, which makes up 90–95% of all diabetes cases. Type 2 ...

Joseph foreshadows Jesus. Both are especially loved by their fathers; hated by their brethren; rejected as rulers over their brethren; conspired against; sold for silver; condemned though innocent; ...

The non-receptor tyrosine kinase Src is important for many aspects of cell physiology. The viral src gene was the first retroviral oncogene to be identified, and its cellular counterpart was the ...

Types of cell signalling pathways include checkpoint signalling, lipid signalling, growth signalling, nutrient signalling, insulin signalling, stress signalling, morphogen signalling, Hippo ...

A youth softball team made up of Santa Clarita Valley kids recently wrapped up a 31-1 winter and fall season, ...