Myeloid FSTL1 deficiency suppresses M1 polarisation, reduces proinflammatory mediator expression and macrophage/neutrophil recruitment and alleviates liver fibrosis. FSTL1 directly binds to pyruvate ...

Intrinsic glycolytic metabolism shapes PD-L1 + macrophages with antitumourigenic properties in HCC. PKM2/HIF-1α axis, elicited by hepatoma cell-derived fibronectin 1, triggers pluripotent polarisation ...

Macrophages exist in most tissues of the body, where they perform various functions at the same time equilibrating with other cells to maintain immune responses in numerous diseases including cancer.

In order to produce the necessary biological effects, macrophages (M0) can be polarized into pro-inflammatory (M1) and anti-inflammatory (M2) types in response to various microenvironmental stimuli.

PPAR-γ is prominently expressed in activated monocytes and tissue macrophages in vivo, including the foam cells of atherosclerotic lesions 6,7. Multiple functions have been proposed for PPAR-γ ...