A common genetic pathway may account for increased risk for atherosclerotic disease in patients with chronic widespread musculoskeletal pain. Chronic widespread pain (CWP) and atherosclerotic disease ...

Researchers have uncovered how specific patterns in brain activity can predict an individual's sensitivity to pain, expanding opportunities for improved pain management strategies. In an ...

Tumor-Secreted Protein May Hold the Key to Better Treatments for Deadly Brain Tumor Jan. 8, 2025 — A study has found targeting a protein called endocan and its related signaling pathway could be ...

Abby said. Abby was told she has what’s called functional abdominal pain — a disorder of the gut-brain interaction. “There is a disorder, there is a disconnect, a miscommunication between ...

Focusing obsessively on pain strengthens the brain’s pain pathways and makes it harder to think about anything else. Mackey’s work has also shown that pain literally diminishes our capacity ...

A recent JAMA Neurology study focussed on determining an effective sensorimotor cortical biomarker for pain based on two metrics, namely, PAF and CME. Over the years, many studies have proposed ...

How does your brain know when you feel pain? How does it know the difference between the soft touch of a feather and a needle prick? And, how does that information get to your body in time to respond?

“If it hadn’t been for a tooth ache, they may not have found this until it got much worse,” said Kathy Olsen, 70, of Twin Lake, Mich. The pain in Olsen’s face started in late January 2024.

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Scientists have developed targeted medications that affect specific pain pathways while minimizing systemic effects. These precision formulations reduce side effects while providing more ...

More information: Hongyun Wang et al, Parallel gut-to-brain pathways orchestrate feeding behaviors, Nature Neuroscience (2024). DOI: 10.1038/s41593-024-01828-8 ...

the exact biological pathways behind the phenomenon remained incompletely understood. “So, all new drugs are up against a mechanism that we don’t fully understand,” said Dussor. In addition to ...