Researchers discovered that ALPK2, a heart-specific enzyme, may protect against HFpEF by activating TPM1 in heart muscle ...

What is ALPK2, and how can it help treat heart failure? Researchers have found that this heart-specific enzyme may prevent ...

Tatsuya Yoshida, Mikito Takefuji, and Toyoaki Murohara in the Department of Cardiology, Nagoya University Graduate School of Medicine, identified an enzyme, alpha-kinase 2 (ALPK2) that is specifically ...

Plant pests such as bacteria and fungi lead to significant yield losses in agriculture. In order to develop new strategies ...

Biologists have identified important components and mechanisms of the molecular machinery that transmits information about a pathogen encounter within the plant organism.

Kim et al. report that two disease mutations in proBMP4, Ser91Cys and Glu93Gly, which disrupt the Ser91 FAM20C phosphorylation site, block the activation of proBMP4 homodimers. Consequently, analysis ...

The team evaluated more than 4,000 clones before identifying an enzyme S N Ar1.3 that contains six mutations and is 160-fold more active than the parent enzyme.

Phosphorylation of proteins at serine residues ... but it's also possible to inhibit an enzyme in the cholesterol pathway that PIN1 stimulates. One class of drugs, called statins, is already ...