2008; Daub et al., 2008). Gygi's group looked at phosphorylation changes across the proteome in the mitotic and G 1 phases of the HeLa cell cycle, using stable isotope metabolic labeling to enable ...

as regulators of progression through the cell cycle. Deregulating CDK activity by changes in phosphorylation, cyclin availability or CDK inhibitors all can drive cells prematurely into both S ...

The following is a summary of “Clinical significance and pro-oncogenic function of DBF4 in clear cell renal cell carcinoma,” published in the January 2025 issue of Urology by Chen et al. Clear cell ...

inhibiting their kinase activity and subsequently reducing RB1 phosphorylation at specific sites, leading to cell cycle arrest in the G1 phase. Further investigation into the role of CDK4/CDK6 in ...

Thanks to Rice researchers' new findings, however, phosphorylation-based innovations in "smart cell" engineering could ... set out to prove—was that each cycle in a cascade can be treated ...