When given as an intravenous bolus, immediate and full platelet inhibition of ADP-induced platelet aggregation was observed. The clinical efficacy and safety of elinogrel will be further evaluated ...
Human platelet lysates (HPL) are abundant in bioactive factors, and numerous studies have demonstrated their beneficial effects on neurological diseases, including their anti-neuroinflammatory ability ...
IPA: Inhibition of platelet aggregation; iv.: Intravenous. The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or ...
A potent and selective inhibitor of 12-LOX, VLX-1005 inhibits platelet 12-HETE production. Two Phase 1 studies completed in 96 healthy participants showed favorable safety and tolerability with no ...
Hence, pathways that regulate macrophage phenotype are of strategic interest, with reprogramming strategies focusing on inhibitors of phosphoinositide 3-kinase-gamma (PI3Kγ) due to restricted immune ...
Platelet-derived growth factor alpha (PDGFRA) plays a significant role in various malignant tumors. PDGFRA expression boosts thyroid cancer cell proliferation and metastasis. Radiorefractory thyroid ...