All COX2 inhibitors undergo oxidative drug metabolism by cytochrome P450 ... 50 is not only a potent inhibitor of platelet aggregation, but also interferes with processes leading to hypertension ...

resulting in low potential drug–drug interactions. When given as an intravenous bolus, immediate and full platelet inhibition of ADP-induced platelet aggregation was observed. The clinical ...

Objective: To compare the effects of parecoxib sodium, an injectable prodrug of a cyclo-oxygenase-2-specific inhibitor, and ketorolac on platelet function and bleeding time in elderly individuals ...