Eledon Pharmaceuticals has a promising anti-CD40L antibody for organ rejection prevention in transplantation. Learn more ...

While nicotine is known to enhance platelet aggregation, its effects on other platelet functions and underlying mechanisms remain unclear. Discussion: In conclusion, nicotine activates αIIbβ3 ...

KFDA approves immune thrombocytopenia treatment Tavalisse from Rigel Pharmaceuticals KFDA greenlights Tavalisse, a groundbreaking therapy for rare platelet disorder by Rigel Pharmaceuticals.

Megakaryocytes (MKs), known for their role in platelet production ... The review emphasizes the expression of immune receptors by MKs, such as toll-like receptors (TLRs), Fc gamma receptors ...

The role of platelets in ICH. BBB, blood–brain barrier; PNAs, platelet–neutrophil aggregates. Upon injury, platelets that have been activated attach to neutrophils through PSGL-1 and CD40, utilizing ...

IPA: Inhibition of platelet aggregation; iv.: Intravenous. The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or ...

APL antibodies bind to dimerized β 2 GPI that in turn binds to platelets receptor(s) (i.e., apoER2', and induce cell activation/aggregation through phosphorylation of p38 MAPK, cPLA2 and release ...