Subsequently, a reactivity function forms a covalent bond ... tool for the isolation of staurosporine-binding kinases from complex protein mixtures. The specificity of the assay is demonstrated ...

Receptor tyrosine kinases function at the beginning of a number of signal transduction cascades, whereas nonreceptor tyrosine kinases and serine/threonine protein kinases function throughout ...

Kinases are proteins involved in many different important cellular functions. "The genome of most mammals, including humans, contains about 500 protein kinases that regulate most aspects of our ...

Kinases are proteins involved in many different important cellular functions. "The genome of most mammals, including humans, contains about 500 protein kinases that regulate most aspects of our ...

Heart failure with preserved ejection function is a lethal form of heart failure, with few effective treatments. A team from ...

is one of a group of proteins called kinases. Kinases are enzymes which modify their targets to regulate many cell functions; they are commonly dysregulated in diseases such as cancer, making them ...

What is ALPK2, and how can it help treat heart failure? Researchers have found that this heart-specific enzyme may prevent ...

Protein tyrosine kinases and protein tyrosine phosphatases coordinate to maintain a protein phospohorylation balance required for normal cell function. If this balance is disrupted, the outcome may be ...

The intricate shapes that proteins fold into—critical to their cellular functions—are more conserved ... the evolutionary relationships of kinases—proteins central to numerous cellular ...

Heart failure with preserved ejection function is a lethal form of heart ... The process is controlled by enzymes called protein kinases, which add a phosphate group to specific amino acids ...

The goal of my laboratory’s research is to understand how fatty acylation influences the structure and function of membrane-bound and secreted signaling proteins. Our focus is on the Src family ...