It relies on an older bioinformatics construct called multiple sequence alignment (MSA), in which a protein’s sequence is compared to evolutionarily similar proteins in order to deduce its ...

Base-pair sequence-alignment programs differentially handle ... twice as much non-coding constrained sequence compared with protein-coding regions. Margulies, E. H., NISC Comparative Sequencing ...

Protein shapes can help untangle life's ancient history A new way of merging genomic and structural data can help dive deep into evolutionary relationships Date: January 15, 2025 Source: Center ...

Proteins have evolved to minimize energetic ... enhancing the energetic frustration features in the input multiple sequence ...

Computational prediction of gene structure is crucial for interpreting genomic sequences ... be annotated by a high identity cDNA or protein alignment, de novo systems—which are the primary ...

For the first time, researchers used data from protein shapes and combined it with data from genomic sequences to improve the reliability of evolutionary trees—which they describe as a critical ...

Bioinformatics approaches including Sequence Alignment to Predict Across Species Susceptibility (SeqAPASS), Molecular Operating Environment (MOE), and iCn3D software were used to compare protein ...