The Food and Drug Administration (FDA) has accepted for Priority Review the New Drug Application for SL1009 (sodium dichloroacetate oral solution) for the treatment of pyruvate dehydrogenase complex ...

Saol Therapeutics, a privately held, clinical-stage pharmaceutical company, announced today that the U.S. Food and Drug ...

A mother has told of her heartbreak at losing both her sons to mitochondrial disease, and her attempts to raise awareness of ...

DCA will be used with a proprietary genetic test to treat an orphan pediatric mitochondrial disease, Pyruvate Dehydrogenase Complex Deficiency (PDCD) 1. The FDA granted Priority Review for the NDA and ...

Lactate can also be converted to lactoyl-CoA, which is involved in the lactylation of histone and non-histone proteins. HK-1, hemokinin-1; G6PD, glucose 6-phosphate dehydrogenase; PKM, glycolytic ...

Findings indicate that altering glucose metabolism in T cells boosts their therapeutic potential against melanoma, paving the way for improved immunotherapies.

Pyruvate dehydrogenase kinase 1 (PDHK1), as an inhibitor of Pyruvate dehydrogenase (PDH), promotes glycolysis, thereby reducing Treg differentiation and function. Similarly, LKB1, which inhibits the ...

Osaka Metropolitan University scientists have developed an artificial photosynthesis technology that produces precursors of biodegradable nylon from biomass-derived compounds and ammonia.

According to Cour, CNP-104 initiates tolerance to pathogenic activated pyruvate dehydrogenase complex-E2 T-cells that “drive inflammation in bile ducts, leading to improvement in clinical outcom ...