The SARS-CoV-2 spike protein (S1), which is used to internalize cells, contains RGD integrin binding domains which are not present within SARS-CoV-1 S1. We investigated whether SARS-CoV-2 S1 binds ...

Another innovative approach combines integrin-targeted PET imaging with immunotherapy. A study introduced a 64 Cu-labeled RGD peptide that not only visualizes tumors but also enhances the ...

Objectives We aimed at presenting a first human dosimetry for 68Ga-NODAGA-RGDyK, visualizing the integrin ανβ3 thanks to its peptide motif Arg-Gly-Asp (RGD). The ανβ3 integrin plays an essential role ...

Integrins are very attractive therapeutic targets in oncology. The anti-tumor mechanisms of integrin-targeting drugs have been validated both in vitroand in vivo. Integrin-targeting drugs are ...

Objectives A divalent knottin 3-4A containing two separate integrin binding epitopes (RGD) in the adjacent loops was recently discovered in our previous report.Here,3-4A was radiofluorinated with a ...

KS1767 cells were detached with cold EDTA and re-suspended in MEM containing 1% BSA. αv integrin-binding RGD-4C phage were used as defined ligands. The cell suspension was incubated with RGD-4C ...

IPF patients had particularly poor outcomes following COVID infection. IPF patients have high levels of the RGD-binding integrin αvβ6 in alveolar epithelium but low levels of ACE2, the primary ...

Materials and methods: We treated MCF-7 cells with T3 (10 nM) for 1 hour in the presence or absence of inhibitors for αvβ3 integrin (RGD peptide), MAPK (PD98059), PI3K (LY294002), and protein ...