Combined with previous studies showing the dependence of rG4 structure on stress and the extreme power of rG4s at oligomerizing proteins, we propose a model of neurodegeneration in which chronic rG4 ...

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This important study reveals a new mechanism for gene regulation in neurons by an RNA binding protein called RBM20 previously studied ... The study shows that neuronal RBM20 governs long pre-mRNAs ...

Enhanced sampling (ES) simulations of biomolecular recognition, such as binding small molecules to proteins and nucleic acid targets ... such as the binding of a peptide to an RNA. In such cases, a ...

Throughout all domains of life, nucleic acids and proteins perform a variety of vital functions, where the sequence-defined structures of these biopolymers either operate on their own or efficiently ...