Quantitative real-time polymerase chain reaction revealed that developmental competence factors are expressed following photoreceptor ... in the NMDA-damaged retina. Moreover, HuC/D, indicative of ...

AIPL1 encodes Aryl-hydrocarbon-interacting-protein-like 1—a photoreceptor-specific cochaperone that interacts specifically with the molecular chaperone HSP90 to modulate the stability of and assembly ...

Researchers are enhancing the best features of AAV capsids and overcoming their limitations to accelerate gene-based therapies.

In this newly developed system, the retina and choroid were automatically stratified into several sub-layers using built-in custom segmentation. The retinal layers were divided into the superficial ...

and to conduct the first clinical study on photoreceptor replacement therapy to restore vision lost through RP and dry AMD. The group has already developed a method for producing clinically viable ...

INM-089 IVT formulation selected for continued developmentDemonstrated successful delivery at doses up to 10 times the projected therapeutic level, indicating a favorable pharmacokinetic profile and a ...

As a result of his retinal appearance, he underwent retinal optical coherence tomography (OCT) (see figure 1b). The OCT images showed destruction of the outer layers (photoreceptors) at the level of ...