Department of Physiology and Pathophysiology (Y.T., Y.J., L.F., H.L., Y.L., J. Zhu., W.P., J. Zhou), School of Basic Medical Sciences, Peking University, Beijing ...

Small GTPases of the Rho family are potent modulators of the actin and microtubule cytoskeleton. Recent data indicate that the Ras-like RAP1 protein and various Rho proteins crosstalk to polarity ...

Proteomics Approaches to Analysis of the Cytoskeleton in Immune Cells Cytoskeletal proteins are often identified in many proteomic studies either as contaminants, owing to their very high ...

This manuscript describes important findings on a rhizobial effector, its cleavage, and legume receptors involved in symbiosis. The evidence supporting the main claims is solid, though some ...

Valo Health’s Rho kinase (ROCK) 1 and 2 inhibitor has failed to reduce the severity of diabetic retinopathy in a phase 2 trial, leading the Flagship-founded biotech to drop the candidate.

They include chemokine receptors, the TCR and integrins such as LFA-1, each being interconnected with the actin cytoskeleton with specific sets of signaling molecules. Ligand-mediated triggering of ...

The exocyst complex is regulated by Rab and Rho small GTPases, resulting in docking of exocytic vesicles to the plasma membrane (PM) and finally their fusion mediated by specific SNARE complexes. In ...

The LPA-induced change in endothelial permeability was accompanied by changes in the F-actin cytoskeleton. In control ECs ... basal permeability and completely prevented the LPA-enhanced HRP passage ...

Insulin under normal circumstances exerts its antiatherogenic action in endothelial cells and VSMCs via the PI 3-kinase signaling pathway. Antiatherogenic aspects of insulin action include ...

Cover picture: Inspired by the Review by Jung-Soon Mo, Hyun Woo Park and Kun-Liang Guan. Illustrated by Sandra Krahl.