Recent studies indicate that chimeric antigen receptor T-cell (CAR-T) therapy has shown promising results in treating B-cell malignancies and may offer a significant breakthrough for non-malignant ...

SLE, the most common and serious form of lupus, is an autoimmune disease driven by antibodies that erroneously target the body’s own healthy tissues, triggering an inflammatory attack. Antibodies are ...

Background B cells play a pivotal role in autoimmune diseases. In SLE, IFN signature is displayed and aberrant function of Toll-like receptors (TLR) for recognizing nucleic acids contributes to its ...

The study by Farge and colleagues 2 offers preliminary but promising evidence for umbilical cord-derived mesenchymal stromal cell therapy as a safe and potentially effective option for treating ...

In mice, B1 and marginal zone (MZ) B-cells play an important role in prevention of autoimmunity through production of regulatory cytokines and natural antibodies. There is limited knowledge about the ...

While there is variability between in vitro studies, SLE DCs exhibit an aberrantly mature and activated phenotype. Relationship Between Type I IFN & Dendritic Cells in SLE IFN-α is produced ...

Objectives Rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and primary Sjögren’s syndrome (pSS) share many clinical manifestations and serological features. The aim of this study was to ...

It is my view that B-cell therapy will likely become an important part of the treatment paradigm in SLE over the next 3–5 years. I think the data are suitably strong to justify the approval of ...

aDivision of Rheumatology, Department of Medicine Solna, Karolinska Institutet, Stockholm SE-17176, Sweden bDepartment of Gastroenterology, Dermatology, and Rheumatology, Karolinska University ...