How are induced pluripotent stem (iPS) cells different from embryonic stem (ES) cells? What can we use iPS cells for? ES cells were originally derived from the inner cell mass (ICM) or epiblast of ...

Somatic stem cells are present in many fetal and post-natal tissues. Somatic stem cells are also capable of self-renewal and, with appropriate signals, differentiate into various cell types from ...

Stem cells derived from adult somatic cells “will carry the mutational history of their past, as well as of any new mutations that occur when you are reprogramming them or growing them in culture,” ...

Stem-cell research has enormous potential value ... the first mammal cloned from the cell of an adult animal.) A somatic cell could be taken from the recipient individual, its nucleus inserted ...

In a groundbreaking shift in our understanding of mutations, researchers have discovered types of DNA damage in healthy cells that can remain unrepaired for years. While most types of DNA damage are ...

New research shows persistent DNA lesions in stem cells contribute to mutations, with links to blood cancers and external mutagens.

Hematopoietic stem cell gene therapy (HSC-GT ... induced hematopoietic stress were found to modulate HSC activity and somatic ...

Research Interests: Somatic Stem Cells and Aging, Genetic Mechanisms of Stem Cell Maintenance, Therapeutic Approaches to Tissue Rejuvenation, Mouse Models of Hair Graying, Melanocyte Stem Cells and ...

The team then confirmed that the iPSCs that they had identified based on physical characteristics exhibited the associated genetic traits of the stem cells they were after, such as a decrease in the ...

The researchers collated seven published sets of these family trees, known as somatic phylogenies. The data set included 103 phylogenies from 89 individuals 1, spanning blood stem cells ...

A team of stem cell scientists successfully spawned mice from two male parents that reached adulthood, a significant step, ...

Scientists at the Wellcome Sanger Institute uncovered DNA damage that can persist for years, evading repair mechanisms and ...