Mayo Clinic researchers find that stem cells with the highest Myc expression become dominant in driving lung remodeling .

Stem-cell differentiation is the process by which a more specialised cell is formed from a stem cell, leading to loss of some of the stem cell's developmental potential. Stem-cell differentiation ...

During development, stem and progenitor cells gradually commit to differentiation pathways. Cell fate decisions are regulated by differentiation factors, which activate transcription programmes ...

These are found in a mature organism. Their function is to replenish all of the types of (differentiated) cells found in that specific tissue. Tissue stem cells are multipotent. This means that ...

Discovering genes and microRNAs involved in human lung development unveils IGFBP3/miR-34a dynamics and their relevance for ...

We investigate how stem cells perceive environmental changes and determine their cell fate, and how niches form and remodel the local environment during lung development, regeneration and disease ...

When cells express specific genes that characterise a certain type of cell we say that a cell has become differentiated ... unspecialised cells are called stem cells.

Gain of functions of STAT5 activation increases stem cell activity through inducing their epithelial niche cell differentiation. His lab's recent finding demonstrates that constitutively activated ...

Morphological profiling allows accurate identification of cell types in dense iPSC-derived cultures, allowing its use for quality control and differentiation monitoring.

Importantly, ontogeny of epidermal SCC parallels cancers associated with high mortality, including the SCC of the head and neck and the lung SCC. Tools for analysis of gene function ... the ...