Impaired expression and regulation of CD39, an ectoenzyme key to immunotolerance maintenance, have been reported in Tregs and effector Th17-cells derived from AIH patients. Interference with these ...

High levels of urea cause the kidneys to produce uremic toxins. Lipid nephrotoxicity could damage the structure and function of the glomerulus and tubules. Figure 2 Differentiation of Treg cells in ...

The ectopic expression of the miR-10a precursor inhibited IL-12/IL-23p40 and NOD2 in DC. Moreover, miR-10a was found to markedly suppress IBD T helper (Th)1 and Th17 cell responses. Conclusions Our ...

Cell death is a process by which a cell's vital capacity is terminated. During an immune response, cells of the immune system cause the death of cells that are infected with microorganisms or are ...

Mechanistically, the DCs promote the differentiation of Foxp3 + Tregs from precursors and/or enhance their survival. Some of these Treg populations are antigen-specific (i.e., their T-cell ...