Special artificial placenta tissues, called "trophoblast organoids," have been developed for studying how harmful substances ...

IN 1949 I published a hypothesis suggesting that the cyto- and syncytio-trophoblast were derived from the granulosa cells that surround the egg when it leaves the ovary; the argument, however ...

While the advent of hTSC and trophoblast organoids in 2018 are major stepping stones, they come with limitations. “Since we have primary cells, then why not use the primary cells for a model system ...

Using a large-scale library of TC organoids they developed, the researchers performed comprehensive comparative analyses of chemo-sensitive and chemo-resistant cells. Their efforts shed light on ...

After implantation, the trophectoderm starts reshaping the endometrium. A layer of cytotrophoblasts—trophoblast progenitor cells—emerges around the same time as the invading primitive syncytium. By 12 ...

Organoids are cell culture models that functionally resemble an organ. They have the potential to speed up drug development, improve understanding of disease treatment in diverse populations ...