Abstract and Introduction Clinical Features of Tuberous Sclerosis Complex Genetics of Tuberous Sclerosis Diagnosis of Tuberous Sclerosis Complex by DNA Analysis References Hypomelanotic macules ...

These skin findings, together with pulmonary lymphangioleiomyomatosis, pointed to the diagnosis of tuberous sclerosis complex (TSC). TSC is a genetic disorder characterized by the presence of ...

Pharmacological interventions mainly include hormones, vitamins and minerals, atypical antipsychotic drugs, phosphodiesterase inhibitors, selective serotonin reuptake inhibitors, mTOR inhibitors, ...

Figure 1. A brief summary of reciprocal regulation between AMPK and mTOR pathways. AMPK is activated by upstream signaling pathways, including LKB1, CaMKKII, and TAK1. AMPK pathway inhibits mTOR ...

Alterations in the expression and activity of specific translation factors, and the uncoupling of translational regulation from inhibition by tumour cell stresses, such as hypoxia and nutrient ...

This phosphorylation leads to the dissociation of Atg13 from a protein complex that contains Atg1 kinase and Atg17, and thus attenuates the Atg1 kinase activity. When mTOR is inhibited ...

Ltd, a biotechnology company specializing in central nervous system (CNS) diseases, to develop, manufacture and commercialise paxalisib as a potential treatment of intractable epilepsy in focal ...

No, Ye and Bianca Censori Weren't Escorted Out of Grammys 2025 Red Carpet ...

Medications are the mainstay of treatment for multiple sclerosis (MS). Many of them are used to block the immune system's attack on the nerves and slow or prevent progression and relapses (flare-ups) ...

41 St. Joseph's Health Care London and University of Western Ontario, London, Ontario, Canada Objective The 1980 American College of Rheumatology (ACR) classification criteria for systemic sclerosis ...

Aortic sclerosis has two important clinical implications. Firstly, aortic sclerosis is an antecedent to clinically significant aortic valve obstruction and, secondly, it acts as a marker of increased ...