Intriguingly, several overlaps have been shown between the two disorders, e.g., inflammatory activation, oxidative stress, glucose and insulin pathways, wingless-INT/mammalian target of rapamycin (Wnt ...

However, primary or acquired resistance to trastuzumab has been increasingly recognized as a major obstacle ... PI3K/Akt is one of the most well studied pathways activated by HER2. Activated PI3K/Akt ...

Alterations in the expression and activity of specific translation factors, and the uncoupling of translational regulation from inhibition by tumour cell stresses, such as hypoxia and nutrient ...

The concept that invalidation of the autophagic process would cause resistance to cell death is ... involves the de-repression of the mTOR Ser/Thr kinase, which inhibits autophagy by ...

"December 2014" -- cover. "The UK Prime Minister commissioned the Review on Antimicrobial Resistance to address the growing global problem of drug-resistant infections. It is chaired by Jim O'Niell ...