uhnresearch.ca Objectives Mammalian target of rapamycin (mTOR) (a serine/threonine protein kinase) is a major repressor of autophagy, a cell survival mechanism. The specific in vivo mechanism of mTOR ...

Hepatocellular carcinoma (HCC) mostly occurs in the background of liver fibrosis, and activated hepatic stellate cells (HSCs) exist in HCC tissues and adjacent tissues. HSC activation is involved ...

Metabolic pathways, such as mitochondrial function, glycolysis, lipid synthesis, glutaminolysis, and mammalian target of rapamycin (mTOR) activation, are involved in the development of renal diseases ...

Crossing TRGL mice with a model of a neurodegenerative disease, the Q175 mouse model of HD, has enabled us to assess disease-related autophagy alterations in the Q175 and TRGL/Q175 models and their ...

Oxidative Stress: Neuropathy, Excitability, and Neurodegeneration.

2025年1月8日，中国科学院脑科学与智能技术卓越创新中心（神经科学研究所）周海波研究组在 Nature 子刊 Nature Aging 上发表了题为：Modulating mTOR-dependent astrocyte substate transitions to alleviate neurodegeneration 的研究论文。 该研究通过多组学时间梯度测序发现，静息状态的 ...

Under normal circumstances, a protein called the low-density lipoprotein receptor (LDLR) helps remove cholesterol from the bloodstream by transporting it into liver cells for breakdown. In individuals ...

From the Hospital Israelita Albert Einstein, São Paulo, SP, Brazil (L.A.P., L.F.G., M.L.) Laboratório de Biologia Vascular, Instituto do Coração (InCor), Hospital ...