Thiophene is a heterocyclic compound with the formula C 4 H 4 S. Consisting of a planar five-membered ring, it is aromatic as indicated by its extensive substitution reactions.It is a colorless liquid with a benzene-like odor.In most of its reactions, it resembles benzene.Compounds analogous to thiophene include furan (C 4 H 4 O), selenophene (C 4 H 4 Se) and pyrrole (C 4 …

Thiophene is a naturally occurring substance found in coal tar and petroleum. It is also produced industrially for use as an organic synthesis reagent and may be released to the environment through a variety of waste streams.

Thiophene, the simplest sulfur-containing aromatic compound, with molecular formula C4H4S, which closely resembles benzene in its chemical and physical properties. It occurs with benzene in coal tar, from which source it was first isolated in 1883.

Thiophene is a privileged pharmacophore in medicinal chemistry owing to its diversified biological attributes. The thiophene moiety has been ranked 4th in the US FDA drug approval of small drug molecules, with around 7 drug approvals over the last ...

Thiophene is a heterocyclic compound of particular interest in the field of organic chemistry. This cyclic molecule, sometimes referred to as thiofuran, consists of four carbon atoms and one sulfur atom in a ring structure.

Thiophene is a five-membered heterocyclic compound containing a sulphur (S) atom (Gramec et al., 2014). Natural thiophenes from plants are reported to be found in many Asteraceae, especially the genus Echinops, Eclipta, Pluchea, Artemisia, Tagetes, Porophyllum, Atractylodes, Atractylodes, and Xanthium (Ibrahim et al., 2016).

For drug design and discovery, thiophene derivatives are privileged structures. Thiophene-based compounds, like the commercial drugs Tinoridine and Tiaprofenic acid, are known for their anti-inflammatory properties.

Thiophene and its substituted derivatives are very important class of heterocyclic compounds which shows interesting applications in the field of medicinal chemistry. It has made an indispensable anchor for medicinal chemists to produce ...

2024年4月17日 · Among the remarkable properties of thiophene derivatives are antibacterial, anti-inflammatory, anti-anxiety, antipsychotic, antiarrhythmic, and anticancer effects.

2025年1月27日 · Thiophene is used as a building block of various organic molecules and pharmaceuticals providing functional properties. Production Methods. Thiophene is present in coal tar and is recovered in the benzene distillation fraction (up to about 0.5% of the benzene present).