Plasmacytoid dendritic cell biology and its role in …
Plasmacytoid dendritic cells (pDCs) are a unique subset of dendritic cells specialised in secreting high levels of type I interferons. pDCs play a crucial role in antiviral immunity and have been implicated in the initiation and development of many autoimmune and inflammatory diseases.
Plasmacytoid Dendritic Cells: Development, Regulation, and …
2019年1月15日 · Plasmacytoid dendritic cells (pDCs) are a unique sentinel cell type that can detect pathogen-derived nucleic acids and respond with rapid and massive production of type I interferon.
The multifaceted biology of plasmacytoid dendritic cells
2015年7月10日 · This Review provides an introduction to human and mouse plasmacytoid dendritic cells (pDCs) and their importance in the immune system. We discuss the phenotypes of human and mouse pDCs and...
Plasmacytoid Dendritic Cells: Physiologic Roles and Pathologic …
Plasmacytoid dendritic cells (PDCs) have perplexed pathologists for decades, undergoing multiple adjustments in nomenclature as their lineage and functions have been characterized.
What Makes a pDC: Recent Advances in Understanding Plasmacytoid …
2019年5月28日 · Plasmacytoid dendritic cells (pDCs) can be derived from both myeloid and lymphoid progenitors. Common DC progenitors (CDPs) arise from lymphoid primed multipotent progenitors (LMPPs) either directly or via macrophage-DC progenitors (MDPs).
Plasmacytoid dendritic cells: origin matters | Nature Immunology
2018年6月20日 · Plasmacytoid dendritic cells (pDCs) are type I interferon–producing cells with antigen-presenting potential. pDC populations are composed of transcriptionally and functionally...
Plasmacytoid dendritic cells (pDCs) are a unique sentinel cell type that can detect pathogen-derived nucleic acids and respond with rapid and massive production of type I interferon.
Dendritic Cells: Definition, Subsets, Function & Significance
Plasmacytoid dendritic cells (pDCs) are a distinct subset of dendritic cells (DCs) that share some features with plasma cells (antibody-producing cells). They are a major source of type I interferons (IFN-α/β), which are crucial for antiviral immunity. pDCs are activated by viral nucleic acids (DNA or RNA) through Toll-like receptors (TLRs ...
Plasmacytoid Dendritic Cell - an overview | ScienceDirect Topics
Plasmacytoid dendritic cells (pDCs) correspond to a specialized dendritic cell population that exhibit plasma cell morphology, express CD4, CD123, HLA-DR, blood-derived dendritic cell antigen-2 (BDCA-2), and Toll-like receptor (TLR)7 and TLR9 within endosomal compartments.
Plasmacytoid dendritic cells in immunity | Nature Immunology
2004年11月17日 · Here we review recent progress on the characterization of plasmacytoid dendritic cell origin, development, migration and function in immunity and tolerance, as well as their effect on human...
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